Ice nucleation impairs
transfer of melanin into
Epidermal cells turn over with less
Cold stress accelerates
Extensive research has been performed using histology and immunohistochemistry techniques to evaluate biopsied skin in treated patients. Human histology shows decreased and diffuse distribution of epidermal melanin post-treatment, with preservation of normal skin architecture and without destruction of melanocytes or other cells.
Treatment of Benign Pigmented Lesions Using a Novel Dermal Cooling System